Professional
Philosophy

I am an educator-scientist who seeks to teach, discover, and lead. I measure my success by the outcomes of my students.

To date, thirty-seven research trainees have qualified for authorship on manuscripts that are published or in process.

Click here to view my bibliography in the Marian University Institutional Repository.

Peer-Reviewed Publications

35. Hsiao Y-T†, Jestes K†, Jackson K†, Zukosky T, Squire ME, Hum JM, Lowery JW∑. “Neuromedin U (NMU) regulates osteoblast differentiation and activity.” Biochemical and Biophysical Research Communications. In Press.

† denotes trainee collaborator

∑ denotes corresponding author

 

34. Lowery JW,∑ Baker J, Gebhardt G, Gorbis S, Hoehn A,† Hum JM, Nelligan L, Sefcik D, Wacker B,† Wagner A, Williams D, Wright A. “Osteopathic medicine and the osteoporosis treatment gap.” Journal of the American Osteopathic Association. In Press.

† denotes trainee collaborator

∑ denotes corresponding author

 

33. Lowery JW∑, Hum JM, Obeime I†, Zahl S, Parr CP, Larsen B, King T, Kisby G. “Influence of research on osteopathic medical student residency match success.” Journal of the American Osteopathic Association. In Press.

† denotes trainee collaborator

∑ denotes corresponding author

 

32. Nguyen V, Kaneshiro K, Nallamala H†, Kirby C†, Cho T, Messer K, Zahl S, Modrzakowski M, Atchley D, Ziegler D, Pipitone O, Lowery JW∑, Kisby G.  “Assessment of the research interests of first-year medical students at four colleges of osteopathic medicine.” Journal of the American Osteopathic Association. In Press.

† denotes trainee collaborator

∑ denotes corresponding author

 

31. De Seta F, Lowery JW, Ogunbekun O†, Larsen B. “Preclinical evaluation of pharmaceutical compositions and their components for urinary health.” Open Journal of Obstetrics and Gynecology, 2020, 10, 151-165.

† denotes trainee collaborator

30. Wagner DR, Karnik S, Gunderson ZJ, Nielsen JJ, Fennimore A, Promer HJ†, Lowery JW, Loghmani MT, Low PS, McKinley TO, Kacena MA, Clauss M, Li J. “Dysfunctional Stem and Progenitor Cells Impair Fracture Healing with Age.” World Journal of Stem Cells. Jun 26, 2019; 11(6): 281-296.

† denotes trainee collaborator

29. Gorrell RE*†, Totten MH*†, Schoerning LJ†, Newby JB†, Geyman L†, Lawless W†, Hum JM, Lowery JW∑. “Identification of commercially available antibodies that block ligand-binding by bone morphogenetic protein type 2 receptor.” BMC Research Notes 2019 Jun 11;12(1):331.
*denotes equal contribution
† denotes trainee collaborator
∑ denotes corresponding author
 

28. Shadmand M†, Jackson K†, Bender C†, Donnelly S†, Guan H†, Tobin K†, Yates S†, Hum J, Lowery JW. “Bringing attention to lesser-known pathways in bone remodeling.” Clinical Reviews in Bone and Mineral Metabolism. 16(3), 95-102.

† denotes trainee collaborator

                                                                                                                                                                                                                                   

27. Lowery JW, Rosen V. “The BMP Pathway and its inhibitors in bone biology.” Physiological Reviews. 98 (4), 2431-2452. PMID: 30156494.

26.  Snyder W†, Leighton B†, Kidd S†, Shively S†, Gorog J†, Lowery JW. "Survey of Current and Prospective Approaches in Bone Grafting Technology." Journal of Musculoskeletal Disorders and Treatment. 4:043. doi.org/10.23937/2572-3243.1510043.

† denotes trainee collaborator

25.   Eaton MS†, Newby JB†, Plattes M, Foster H, Arthur J†, Ward T†, Wauson EM, Dewar B, Arthur J†, Lowery JW∑.  “Loss of the nutrient sensor Tas1R3 leads to reduced bone resorption.” Journal of Physiology and Biochemistry. 2018 Feb;74(1):3-8. doi: 10.1007/s13105-017-0596-7. PMID: 29019082.

† denotes trainee collaborator

∑ denotes corresponding author

24.    Kokabu S, Nakatomi C, Matsubara T, Ono Y, Addison WN, Lowery JW, Hudnall AM†, Hitomi S, Tsukamoto S, Nakatomi M, Sato T, Yoda T, Rosen V, Jimi E. “TLE3 regulates myogenesis by repressing the transcriptional activity of MyoD.” Journal of Biological Chemistry. 2017 Aug 4;292(31):12885-12894. doi: 10.1074/jbc.M116.774570. PMID: 28607151.

† denotes trainee collaborator

23. Lowery JW, Rosen V. “Bone morphogenetic protein-based therapeutic approaches.” Cold Spring Harbor Perspectives in Biology. 2017 Apr 7. pii: a022327. doi: 10.1101/cshperspect.a022327. PMC5546029. PMID: 28389444.

22. Kokabu S, Lowery JW, Sato T, Yoda T. “On the emerging role of the taste receptor type 1 (T1R) family of nutrient-sensors in the musculoskeletal system.” Molecules. 2017, 22(3), 469. PMC: In Process. PMID: 28294983.

21. King T†, de Caestecker M, Lowery JW∑. “Reply to ‘Bone morphogenetic protein’s contribution to pulmonary artery hypertension.’” Surgical Neurology International. 2016 Oct 19;7:91. eCollection 2016. PMC5093875. PMID: 27857855.

† denotes trainee collaborator

∑ denotes corresponding author

20. Lowery JW∑, Ankrum JA, Kokabu S, Liu R. “Targeted Strategies to Modulate Stem-Cell-Relevant Pathways.” Stem Cells International. 2016:1859456. PMC5040791. PMID: 27703484.

∑ denotes corresponding author

19. Lowery JW∑, Brookshire B†, Rosen V. “A survey of strategies to modulate the Bone Morphogenetic Protein (BMP) signaling pathway: current and future perspectives.“ Stem Cells International. 2016:7290686. PMC4940573. PMID: 27433166.

† denotes trainee collaborator

∑ denotes corresponding author

18. Hudnall AM†, Arthur JW†, Lowery JW∑. “Clinical relevance and mechanisms of antagonism between the BMP and Activin/TGFβ signaling pathways.” Journal of the American Osteopathic Association. 2016 Jul 1;116(7):452-61. PMID: 27367950.

† denotes trainee collaborator

∑ denotes corresponding author

17. Kokabu S, Lowery JW, Jimi E. “Cell fate and differentiation of bone marrow mesenchymal stem cells.” Stem Cells International. 2016;2016:3753581. PMC4889852. PMID: 27298623.

16. Kokabu S, Sughiyama G, Tsuchiya-Hirata S, Lowery JW, Jimi E. “Inhibition of BMP-induced osteoblast differentiation.” Journal of Oral Biosciences. 2015 Nov;57(4):179-184.

15. Kokabu S, Lowery JW, Toyono T, Seta Y, Hitomi S, Sato T, Enoki Y, Okubo M, Fukushima Y, Yoda T. “Muscle regulatory factors regulate T1R3 taste receptor expression.” Biochemical and Biophysical Research Communications. 2015 Dec 25;468(4):568-73. PMC In Process. PMID: 26545778.

14. Lowery JW, Intini G, Gamer L, Lotinun S, Salazar V, Ote S, Cox K, Baron R, Rosen V. “Loss of BMPR2 leads to high bone mass due to increased osteoblast activity.” J Cell Sci. 2015 Apr 1;128(7):1308-15. PMC4379725. PMID: 25663702.

Citations: 6

                                                                                                                                       

13. Lowery JW, Amich JM†, Andonian A†, Rosen V. “N-linked glycosylation of the Bone Morphogenetic Protein Type 2 Receptor (BMPR2) enhances ligand binding.” Cell Mol Life Sci. 2014; 71:3165-3172. PMC4058410. PMID: 24337809.

† denotes trainee collaborator

Citations: 1                                                                                                                                           

12. Frump AL, Lowery JW, Hamid R, Austin ED, de Caestecker M. “Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with Heritable Pulmonary Arterial Hypertension.” PLoS One. 2013 Nov;8(11):e80319. PMC3818254. PMID: 24224048.

Citations: 14                                                                                                                                          

11. Lowery JW, LaVigne AW†, Kokabu S, Rosen V. “Comparative genomics identifies the mouse Bmp3 promoter and an upstream evolutionary conserved region (ECR) in mammals.” PLoS One. 2013 Feb;8(2):e57840. PMC3579780. PMID: 23451274.           

† denotes trainee collaborator

                                                                                                                                                                 

10. Chappuis V, Gamer L, Cox K, Lowery JW, Bosshardt D, Rosen V. “Periosteal BMP2 activity drives bone graft healing.” Bone. 2012 Oct;51(4):800-809. PMID: 22846673.

9. Kokabu S, Gamer L, Cox K, Lowery JW, Kunikazu T, Econimedes A, Katagiri T, Rosen V. “BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.” Mol Endocrinol. 2012;26(1):87-94. PMC3248326. PMID: 22074949.

Citations: 47                                                                                                                               

8. Lowery JW, de Caestecker M. “Bmp signaling and vascular disease.” Encyclopedia of Biological Chemistry, 2nd edition. ISBN: 9780123786302. 2013(1):229-239. DOI: 10.1016/b978-0-12-378630-2.00356-x

7. Lowery JW and Rosen V. “Allele-specific RNA interference in FOP: Silencing the FOP gene.” Gene Ther. 2012 Jul;19(7):701-702. PMID: 22130446.

6. Lowery JW, Pazin D, Intini G, Kokabu S, Chappuis V, Capelo LP, Rosen V. “The role of BMP2 signaling in the skeleton.” Crit Rev Eukaryot Gene Expr. 2011;21(2):177-85. PMID: 22077155.

5. Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V. “BMPR-II is dispensable for formation of the limb skeleton.” Genesis. 2011 Sep;49(9):719-24. PMID: 21538804.

4. Lowery JW, Frump AL, Anderson LA, diCarlo GE†, Jones MT, de Caestecker M. “ID family protein expression and regulation in hypoxic pulmonary hypertension.” Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1463-77. PMC3007180. PMID: 20881097.                                                                                                                                                          

† denotes trainee collaborator

3. Lowery JW, de Caestecker M. “BMP signaling in vascular development and disease.” Cytokine & Growth Factor Reviews. 2010 Aug;21(4):287-298. PMC2939258. PMID: 20674464.

2. Anderson LA* & Lowery JW*, Frank DB, Jones MT, Mortlock DP, Chandler RL, de Caestecker M. “Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension.” Am J Phsyiol Regul Integr Comp Physiol. 2010 Mar;298(3):R833-42. PMC2838658. PMID: 20042692.                                                                                                                                                   

* denotes equal contribution

1. Frank DB, Lowery J, Anderson L, Brink M, Reese J, de Caestecker M. “Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature.” Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L98-L109. PMID: 18024717.

Peer-Reviewed Conference Proceedings

15. Totten M†, Yates S†, Jestes K†, Chlebek S†, Newby J†, Arthur J†, Lowery JW. “Antagonism between Bone Morphogenetic Protein and Activin signaling pathways in osteoprogenitor cells.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Montreal, Canada, 2018. J Bone Miner Res 33 (Suppl 1).

† denotes trainee collaborator

14.    Jackson K†, Hudnall A†, Lowery JW∑. “Identification of a gene signature associated with elevated bone formation rate in aging mice.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Denver, CO, 2017. J Bone Miner Res 32 (Suppl 1).
† denotes trainee collaborator
∑ denotes corresponding author

13.    Weinstein N†, Eaton M†, Shively S†, Lowery JW∑. “Nutrient sensing by Tas1R proteins is required for normal bone resorption.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Denver, CO, 2017. J Bone Miner Res 32 (Suppl 1).
† denotes trainee collaborator
∑ denotes corresponding author

12.    Schoerning L†, Gorrell R†, Newby J†, Lowery JW∑. “Identification of commercially-available antibodies that block ligand-binding by BMPR2.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Denver, CO, 2017. J Bone Miner Res 32 (Suppl 1).
† denotes trainee collaborator
∑ denotes corresponding author

11. Eaton MS†, Newby JB†, Hudnall JB†, Rosen V, Lowery JW∑. “Loss of BMPR2 expression in skeletal progenitor cells reduces age-related bone loss.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Atlanta, GA, 2016. J Bone Miner Res 31 (Suppl 1).

† denotes trainee collaborator

∑ denotes corresponding author

10. Eaton MS†, Newby JB†, Plattes M, Foster H, Wauson EM, Dewar B, Arthur J†, Lowery JW∑. “Loss of the nutrient sensor Tas1R3 leads to reduced bone resorption.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Seattle, WA, 2015. J Bone Miner Res 30 (Suppl 1).

† denotes trainee collaborator

∑ denotes corresponding author

9. Lowery J, Intini G, Gamer L, Cox K, Rosen V. “Type 2 receptor-level competition between BMP and Activin ligands regulates postnatal bone mass.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Baltimore, MD, 2013. J Bone Miner Res 28 (Suppl 1).

8. Kokabu S, Gamer L, Lowery J, Sato T, Yoda T, Katagiri T, Rosen V. “BMP3 expression by osteoblasts is regulated by canonical Wnt signaling.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Baltimore, MD, 2013. J Bone Miner Res 28 (Suppl 1).

7. Lowery JW, LaVigne AW†, Kokabu S, Rosen V. “Comparative genomics identifies the mouse Bmp3 promoter and an upstream evolutionary conserved region (ECR) in mammals.” Presented at the American Physiological Society Annual Meeting (Experimental Biology 2013). FASEB  J April 9, 2013 27:1212.10.

† denotes trainee collaborator

6. Smith EA†, Lowery JW, Gamer LW, Cox KA, Rosen V. “Spatial expression of Bone Morphogenetic Protein-2 (BMP2) in the pulmonary vasculature.” Presented at the International Association for Dental Research General Session 2013. J Dent Res 92(Spec Iss A):2595, 2013.

† denotes trainee collaborator

5. Lowery JW, Intini G, Cox K, Gamer L, Lotinun S, Tsuji K, Baron R, Rosen V. “Loss of BMPR2 leads to high bone mass due to increased osteoblast activity.” Presented at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Minneapolis, MN, 2012. J Bone Miner Res 27 (Suppl 1).

4. Frump A, Lowery J, de Caestecker M. “Effects of different BMPR2 mutations on pulmonary endothelial cells from patients with hereditary arterial pulmonary hypertension.” American Thoracic Society (ATS) International Conference, Denver, CO, 2011. Am J Respir Crit Care Med 183;2011:A5011.

3. Lowery JW, Anderson L, Jones M, de Caestecker MP. “The role and regulation of Inhibitor of Differentiation (Id) family members in hypoxic pulmonary hypertension.” Presented at the American Physiological Society Annual Meeting (Experimental Biology 2010). FASEB J April 6, 2010 24:1023.7.

2. de Caestecker MP, Anderson L, Jones M, Lowery J. “Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension.” Presented at the American Physiological Society Annual Meeting (Experimental Biology 2010). FASEB J 2010 April 6, 2010 24:1023.3.

1. Moore M, Edwards JR, Lwin S, Lowery J, Zhao M, Garrett R, Gutierrez GE, Mundy GR. “BMP2-eNOS axis is essential for normal skeletal development and statin-induced bone formation.” American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Denver, CO, 2009. J Bone Miner Res 24 (Suppl 1).

© 2017 Jonathan Lowery